Indications & Usage

Enoxaparin Sodium Injection is indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients:

• Undergoing abdominal surgery who are at risk of thromboembolic complications
• Undergoing hip-replacement surgery, during and following hospitalization
• Undergoing knee-replacement surgery
• At risk for thromboembolic complications due to severely restricted mobility during acute illness

Enoxaparin Sodium Injection is indicated for treatment of acute DVT:

• The INPATIENT TREATMENT of acute DVT, with or without PE, when administered in conjunction with warfarin sodium
• The OUTPATIENT TREATMENT of acute DVT, without PE, when administered in conjunction with warfarin sodium

Enoxaparin Sodium Injection is indicated for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.

Enoxaparin Sodium Injection, when administered concurrently with aspirin, has been shown to reduce the rate of the combined endpoint of recurrent myocardial infarction or death in patients with acute STEMI receiving thrombolysis and being managed medically or with percutaneous coronary intervention (PCI).

The information presented here does not take the place of injection instructions you may have received from your health care provider.

Please see full Prescribing Information including Boxed WARNING »

The Dos and Don'ts of Continuing Treatment

• DO alternate injection site with every injection
• DO administer enoxaparin at the same time every day
• DO look for unusual signs of bleeding
• DO store enoxaparin at room temperature, away from light and moisture
• DO use a new syringe if the safety shield is accidentally activated before use; safely store away the defective syringe and call your pharmacist for more information
• DO tell your doctor about other medications you may be taking, including those that do not require a prescription

• DON’T give enoxaparin to anyone other than the person it was prescribed for
• DON’T take the following medications while taking enoxaparin, unless otherwise instructed by your doctor. They may increase your risk of bleeding:
• - ASPIRIN OR ASPIRIN-CONTAINING PRODUCTS
• - OTHER PLATELET INHIBITORS
• - SALICYLATES (ASPIRIN-LIKE PRODUCTS)
• - NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS), SUCH AS IBUPROFEN, NAPROXEN, OR KETOROLAC
• - COLD OR ALLERGY PRODUCTS, OR PAIN RELIEVERS THAT CONTAIN ANY OF THE ABOVE DRUGS

YOU SHOULD CALL YOUR HEALTH CARE PROFESSIONAL RIGHT AWAY IF YOU NOTICE ANY OF THE FOLLOWING:

• Bleeding or oozing from surgical wound
• Any other bleeding episodes; for example, bleeding at the site of the injection, nosebleeds, blood in your urine, or if you cough or vomit blood
• Spontaneous bruising (a bruise not caused by a blow or any apparent reason)
• Pain or swelling in any part of your leg, foot, or hip
• Dizziness, numbness, or tingling
• Rapid or unusual heartbeat
• Chest pain or shortness of breath
• Vomiting, nausea, or fever
• Confusion

The information presented here does not take the place of injection instructions you may have received from your health care provider.

Please see full Prescribing Information including Boxed WARNING »

What is Deep Vein Thrombosis (DVT)?

DVT is a condition in which a blood clot, called thrombus, forms in one or more of the deep veins in the body, usually in the lower leg or thigh. Most often, a DVT blood clot occurs when blood flow is slowed following surgery, prolonged hospital stays, or extended bed rest due to injury or illness.

If a DVT blood clot breaks off and travels to the lungs, it can become lodged there, blocking blood flow and leading to a pulmonary embolism (PE), an extremely serious and potentially fatal condition.

What Increases Your Risk of DVT Blood Clots?

• Advanced age
• Birth control pills, pregnancy, and hormone replacement therapy (HRT)
• Certain types of cancer and its treatment
• Respiratory failure
• Chronic obstructive pulmonary disease (COPD)
• Clotting disorders
• Congestive heart failure (CHF)
• Obesity
• Prior DVT blood clot
• Prolonged immobility
• Surgery (abdominal surgery, knee- or hip-replacement surgery)

What Are the Warning Signs of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE)?

As many as half of all DVT blood clots occur without any noticeable symptoms.

Call your doctor immediately if you experience any of the following warning signs of a DVT blood clot:

• Swelling, discoloration, or redness in the leg
• Pain or tenderness in the leg
• Warmth over the leg

Call your doctor immediately if you experience any of the following warning signs of PE in your lung:

• Chest pain
• Rapid pulse (racing heartbeat)
• Rapid breathing
• Shortness of breath
• Cough, with or without blood
• Fatigue
• Low-grade fever up to 101°F

How Can You Reduce Your Risk of Deep Vein Thrombosis (DVT)?

The choices you make in your day-to-day activities can go a long way toward reducing your risk of DVT.

• Ask your doctor about blood-flow enhancing exercises
• Check with your doctor before taking any new medications, vitamins, or supplements
• Do not smoke
• Maintain a healthy weight
• Talk to your doctor about any changes in your health
• Try to avoid extended periods of sitting—moving your feet or stretching your legs in a seated position can help

Before starting a new diet or exercise plan, be sure to talk to your doctor.

Important Safety Information for Enoxaparin Sodium Injection
The most common side effects from the use of Enoxaparin Sodium Injection are mild pain, irritation, bruising, or redness of the skin at the site of injection. Other common side effects include bleeding, anemia, diarrhea, nausea, ecchymosis, fever, edema, peripheral edema, dyspnea, confusion, and injection site pain. Please see additional Important Safety Information »

The information presented here does not take the place of injection instructions you may have received from your health care provider.

Please see full Prescribing Information including Boxed WARNING »